Table 1.
Domain spacing (dPEG) and diameter (DPEG) determined from small-angle X-ray scattering (SAXS) data of dry and hydrated polymer matrices loaded with voclosporin.
| Polymer composition | dPEG (Å), for polymer + VCS | DPEG (Å), for polymer + VCS | ||||||
|---|---|---|---|---|---|---|---|---|
| dry | 1 wk | 4 wk | 7 wk | Dry | 1 wk | 4 wk | 7 wk | |
| E0000 | - | - | - | - | - | - | - | - |
| E0400 | 247 | 283 | 425 | 291 | 204 | 183 | 234 | 229 |
| E0800 | 291 | 440 | - | 331 | 234 | 224 | 229 | |
| E1200 | 274 | 446 | 464 | 414 | 234 | 302 | 276 | 280 |
| E0304.5 | - | - | 323(b) | - | - | - | 159(b) | - |
| E0904.5 | - | - | 321(b) | - | - | - | 220(b) | - |
| E0006 | - | 212 | 213 | 264 | - | 132 | 172 | 234 |
| E1206 | - | 137(a) | 244 | - | 132(a) | 203 | - | |
| E0609 | - | 166 | 214 | 304 | - | 125 | 166 | 264 |
| E0012 | - | 194 | 246 | 333 | - | 137 | 159 | 222 |
| E1212 | - | 133 | 157 | 297 | - | 124 | 183 | 305 |
| E0313.5 | - | 149(a) | 180 | 266 | - | 156(a) | 178 | 253 |
| E0913.5 | - | 138 | 148 | 256 | - | 118 | 159 | 258 |
| E0018 | - | 133 | 154 | 228 | - | 163 | 176 | 225 |
| E0418 | - | 137 | 143 | 210 | - | 128 | 156 | 213 |
| E0818 | - | 121 | 135 | 201 | - | 124 | 145 | 209 |
| E1218 | - | 101 | 132 | 204 | - | 121 | 159 | 213 |
| E1818 | - | (c) | (c) | 192 | - | (c) | (c) | 197 |
| E1420 | - | 99 | (c) | 179 | - | 93 | (c) | 178 |
| E1224 | - | 93 | (c) | 175 | - | 105 | (c) | 179 |
| E1230 | - | 81 | (c) | 133 | - | 80 | (c) | 134 |
| DT homopolymer | - | - | - | - | - | - | - | - |
| PEG homopolymer | 126 | (c) | (c) | (c) | 146 | (c) | (c) | (c) |
The absence of values indicates that no interference peak was detected: (a) Not used for PEG trend analysis due to appearance of split peaks; (b) Not used for PEG trend analysis since PEG content < 6 mole%; (c) Not able to test since sample was fragmented.