Table 4.

List of strategies and approaches to modify reactivity of the self-setting calcium orthophosphate formulations [235].

Strategy	Approach	Sub-approaches
1. Dissolution rate	1.1. Change contact area between reagent and mixing liquid	1.1.1. Change milling duration
		1.1.2. Use nano- or micron-sized powders
	1.2. Change solubility in the mixing liquid	1.2.1. Use more/less soluble phase
		1.2.2. Change of reaction pH
	1.3. Change saturation of the mixing liquid
	1.4. Use dissolution inhibitors in the mixing liquid
	1.5. Modify reagent surface	1.5.1. Chemical change (pre-reaction)
		1.5.2. Physical change (dissolution pits)
2. Nucleation rate	2.1. Use crystallization nuclei
	2.2. Change the saturation of the reaction product in the mixing liquid	2.2.1. Change of saturation
		2.2.2. Change of end-product solubility
	2.3. Use nucleation inhibitors
3. Growth rate	3.1. Change the saturation of the reaction product in the mixing liquid	3.1.1. Change of saturation
		3.1.2. Change of end-product solubility
	3.2. Use crystal growth inhibitors