Table 2.

IC₅₀ values of Cd²⁺, Hg²⁺, Pb²⁺ and NaAsO₂ for the inhibition of protein refolding.

	IC50 value (nM)
	Cd2+	Hg2+	Pb2+	NaAsO2
Luciferase
Spontaneous refolding	66 ± 11	40 ± 3	63 ± 6	426 ± 4
Chaperone-assisted refolding	100 ± 5	53 ± 2	140 ± 11	297 ± 13
Chaperone-mediated disaggregation	280 ± 4	210 ± 16	325 ± 11	613 ± 31
Lactate dehydrogenase
Spontaneous refolding	68 ± 2	58 ± 6	74 ± 9	ND
Malate dehydrogenase
Spontaneous refolding	300 ± 45	290 ± 16	520 ± 44	ND
Glucose-6-phosphate dehydrogenase
Spontaneous refolding	340 ± 15	230 ± 18	>600	ND

* IC₅₀ values with SEM from three independent experimental datasets [7,9]. The values given are apparent values determined at a protein concentration of 350 nM (see text). ND: not determined.