Table 1.

Properties of PLGA-ALE NP prepared by the solvent evaporation method (using different solvents) or by a dialysis method.

Production method	Zeta Potential (mV)	Mean Particle Size (nm)	PDI
Solvent evaporation (organic phase)
Acetone	−37.6 ± 4.1	188.0 ± 21.3	0.258
DMSO	−38.9 ± 3.7	286.9 ± 9.60	0.156
Acetone/DMSO (1:1, v/v)	−37.2 ± 5.0	198.7 ± 17.3	0.348
Dialysis	−39.3 ± 4.7	438.6 ± 11.1	0.033