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. 2014 May 22;10(5):e1003520. doi: 10.1371/journal.pcbi.1003520

Figure 5. Assume that the adaptive steps, colored blue, connect three genotypes with relavatively high fitness.

Figure 5

Most connecting arrows point toward the starting point, as well as the end point of the adaptive steps. Note that due to the high fitness of the genotypes along the adaptive walk, the arrows emanating from the fourth genotype in the quadruple are more likely to point outward. The result in such a case is sign epistasis.