Table 5. Drug resistant trypanosome stabilates stored at the Kenya Trypanosomiasis Research Institute cryobank.
| Species | Stabilates | Trypanocidal Drug(s) | Dose level | References |
| T. b. rhodesiense* | KETRI 2538, 2694, 2709, EATRO 237, 243, 240, & 1992 | Melarsoprol | 4×20 mg/kg | [1] |
| T. b. rhodesiense | EATRO 243, KETRI 2708, KETRI 2538 | Melarsoprol | 1, 5, & 10 mg/kg | [19] |
| T. b. rhodesiense | 3150a, 3151a & 3152a | Melarsoprol | 3.6 mg/kg×4 | KARI-TRC, unpublished data |
| T. b. rhodesiense* | EATRO 243 | Melarsoprol; Melarsen oxide | 1.0, 2.0, 5.0, & 10 mg/kg; 1.0, 5.0 & 10 mg/kg | [20] |
| T. b. rhodesiense | KETRI 2002 | Melarsoprol, Melarsen oxide | 1.0 mg/kg; 1.0, 2.0, 5.0, & 10 mg/kg | [20] |
| T. b. rhodesiense | KETRI 2538 | Melarsoprol, Melarsen oxide | 1.0, 2.0, 5.0, & 10 mg/kg | [20] |
| T. b. rhodesiense* | EATRO 243, 1992, & KETRI 2538 | Diminazene | 10 mg/kg | [19] |
| T. b. rhodesiense | EATRO 243, 269, 1992, & KETRI 2538 | Pentamidine | 2 mg/kg | [19] |
| T. b. rhodesiense | EATRO 265, 269, & KETRI 2538 | DFMO | 2% and 4% | [19] |
| T. b. rhodesiense* | EATRO 237, KETRI 2538, 2694 | Samorin, Diminazene, Homidium Mel B | 1.0 mg/kg; 20 mg/kg; 1.0 mg/kg; 10 mg/kg | [21] |
| T. b. rhodesiense* | KETRI 3530 | Diminazene; Homidium | 20 mg/kg; 1.0 mg/kg | [21] |
| T. b. rhodesiense* | KETRI 2579, 2630, 2628, 2606, 2605, 2604, & 2653 | Suramin* | Dose level administered to patients not indicated. | KARI-TRC, unpublished data |
| T. congolense | KETRI 2776 | Diminazene | 3.5 & 7.5 mg/kg | [22] |
| T. congolense | KETRI 2880 | Diminazene, Samorin | 7.0 mg/kg; 0.5–1.0 mg/kg | [22] |
| T. congolense | KETRI 2883 | Diminazene | 10.5 mg/kg | [23] |
| T. evansi | EATRO 1188, KETRI 2411, 2415, & 2424 | Diminazene, Samorin, Ethidium, Novidium | 3.5, 7.0, 10.5 mg/kg; 0.5, 1.0, 2.0, 4.0, & 8.0 mg/kg; 1.0, 2.0, 3.0 mg/kg; 1.0, 2.0, 3.0 mg/kg | [24] |
Other than KETRI 2538, which is molecularly characterized (not published), molecular characterization of the other isolates is not available. Key: * = these isolates were recovered from cases of treatment failure following suramin chemotherapy; a = stabilates which were made resistant to melarsoprol in the laboratory; EATRO = East African Trypanosomiasis Research Organization; KETRI = Kenya Trypanosomiasis Research Institute; DFMO = difluoromethylornithine.