Skip to main content
. 2014 May 22;9(5):e98143. doi: 10.1371/journal.pone.0098143

Figure 3. Measurement of TNF-α concentration in the frontal cortex and serum after LPS injection (i.p.).

Figure 3

A: Control animals (n = 7) received normal sterile saline (0.5 ml; i.p.) after the collection of baseline cOFM samples, whereas the LPS-treated group (n = 7) were injected with LPS (i.p.; 5 mg/kg dissolved in 0.5 ml normal sterile saline) after baseline cOFM sample collection. TNF-alpha concentration in the control animals and in the baseline cOFM sample as well as 1 h after LPS injection was very close to the lower limit of quantification (0.004 ng/ml). B: Serum TNF-alpha concentration in control animals and in the baseline sample of the LPS-treated group was below the lower limit of quantification. The serum level of TNF-alpha was found to be significantly elevated from 2 to 6 h after LPS injection. Results are shown as mean ± SEM. (* p<0.05; ** p<0.01).