Figure 5. Dacomitinib, with or without ionizing radiation, perturbed the cell cycle in SCCHN cells.

(A-C) FaDu, UT-SCC-8, and UT-SCC-42a cells were treated with negative control (DMSO), Dacomitinib (100 nM), IR (4 Gy), or Dacomitinib plus IR (100 nM; 4 Gy). Cells were fixed at 48 or 72 hours post-treatment, then analysed. The plots represent data from three independent experiments, with the mean ± SEM reported. *p<0.05; **p<0.01; ***p<0.001; Student's t test.