. 2014 May 22;10(5):e1004145. doi: 10.1371/journal.ppat.1004145

Table 1. Mutation frequencies in MLV and MMTV proviruses in splenic DNA of infected A3A and A3G mice.

	Total sequenced	unique clones	# mice	# w/G to A	# w/o G to A	# G to A mutations	# other mutations	G to A kb	Other kb	GG	GA	GC	GT
A3G^high M-MLV	56	42	4	32	24	158	34	5.14	1.11	149	7	1	1
A3G^low M-MLV	47	28	4	23	24	35	48	1.33	1.82	33	2	0	0
A3A^high M-MLV	49	9	4	0	49	0	7	0.00	0.26	0	0	0	0
A3A^low M-MLV	47	17	4	4	43	4	38	0.16	1.47	0	1	1	2
KO M-MLV	54	24	4	2	52	2	34	0.07	1.15	1	0	0	1
A3G^high MMTV	57	40	4	29	28	68	59	1.77	1.54	58	8	1	1
A3G^low MMTV	52	31	4	19	33	27	58	0.77	1.66	14	4	8	1
A3A^high MMTV	52	29	4	6	46	12	62	0.34	1.77	1	10	1	0
A3A^low MMTV	41	20	3	4	37	4	46	0.14	1.67	2	1	1	0
KO MMTV	40	20	3	3	37	3	64	0.10	2.16	1	2	0	0
A3G^high F-MLV	41	25	3	27	14	116	43	4.83	1.79	113	2	1	0
A3G^high F-MLV-vif	53	23	4	6	47	12	71	0.39	2.29	11	0	0	1
A3G^low F-MLV	40	18	3	18	22	27	19	1.15	0.81	21	1	2	3
A3G^low F-MLV-vif	41	16	3	1	40	2	28	0.08	1.16	1	1	0	0
KO F-MLV	42	11	3	3	39	7	37	0.28	1.50	5	1	1	0
KO F-MLV-vif	42	42	3	1	41	1	67	0.04	2.72	1	0	0	0

Analysis was performed on the cloned DNA represented in Figure 4 (3–4 mice/group; 10–15 sequences/mouse). Unique clones were distinguished by their mutation pattern. M-MLV has a total of 47 GG and 33 GA motifs in the 549bp target sequence, MMTV has 34 GGs and 56 GAs in 673bp and F-MLV has 58 GG and 29 GA motifs in 586bp.