Table 1.
Clinicopathologic and pre-operative characteristics of patients undergoing planned hepatectomy
| Total (n = 599) | Chemoprophylaxis (n = 454) | No chemoprophylaxis (n = 145) | P value | |
|---|---|---|---|---|
| Age, years (IQR) | 58 (49 to 67) | 58 (50 to 68) | 57 (47 to 64) | 0.05 |
| Male sex | 297 (49.6) | 227 (50) | 75 (51.7) | 0.72 |
| Ethnicity | 0.06 | |||
| Caucasian | 489 (81.6) | 363 (80.0) | 126 (86.9) | |
| Other | 110 (18.4) | 91 (20.1) | 19 (13.1) | |
| ASA Score | 0.60 | |||
| I–II | 154 (25.9) | 113 (25.0) | 41 (28.7) | |
| III–IV | 441 (74.1) | 339 (75.0) | 102 (71.3) | |
| ECOG Performance Status | 0.67 | |||
| 0 | 266 (73.7) | 258 (74.1) | 8 (61.5) | |
| 1 | 90 (24.9) | 85 (24.4) | 5 (38.5) | |
| 2 and 3 | 5 (1.4) | 5 (1.5) | 0 | |
| History of VTE | 30 (5.0) | 29 (6.4) | 1 (0.7) | 0.006 |
| Diagnosis | 0.004 | |||
| Malignant | 544 (90.8) | 421 (92.7) | 123 (84.8)) | |
| Benign lesion | 55 (9.2) | 33 (7.3) | 22 (15.2) | |
| Pre-operative INR (IQR) | 1 (0.9 to 1.0) | 1 (0.9 to 1.0) | 0.9 (0.9 to 1.0) | <0.001 |
| Pre-operative hematocrit (IQR) | 39 (35.8 to 41.2) | 38.8 (35.8 to 41.1) | 39.5 (35.8 to 42.0) | 0.13 |
| Post-operative hematocrit (IQR) | 30.6 (27.1 to 33.5) | 30.4 (26.9 to 33.4) | 31.0 (27.6 to 33.9) | 0.11 |
| Post-operative % hematocrit change (IQR) | –27.1 (–40.8 to –14.5) | –26.4 (–41.7 to –13.9) | –27.2 (–40.0– –14.5) | 0.28 |
| Pre-operative therapy, no. (%) | <0.001 | |||
| None | 419 (70.0) | 316 (69.6) | 103 (71.0) | |
| Surgery | 34 (5.7) | 14(3.1) | 20 (13.8) | |
| Ablation or IAT | 15 (2.5) | 11 (2.4) | 4 (2.8) | |
| Systemic Chemotherapy | 128 (21.4) | 110(24.2) | 18 (12.4) | |
| Portal vein embolization | 3 (0.5 | 3 (0.7) | 0 |