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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Epilepsia. 2014 Apr 4;55(5):e44–e49. doi: 10.1111/epi.12603

Figure 1. The ketogenic diet diminishes pathologic features of SPW-HFO generated in KO hippocampal slices.

Figure 1

A. Examples of SPW-HFOs recorded in the CA3 stratum radiatum region of hippocampal slices from WT, KO and KD treat KO (KO-KD) mice. Top trace: raw signal. Second trace: raw signal band pass filtered between 100-175 Hz. Third trace: raw signal band pass filtered between 200-600 Hz. Bottom trace: Time-frequency map of raw signal band pass filtered between 100-600 Hz.

B. SPW intervals and durations are increased by KD treatment [n = 6 (WT), 11 (KO), 11 (KO-KD) slices]. Significance determined by an one-way ANOVA followed by Tukey’s multiple comparison test, *p<0.05, **p<0.01, ***p<0.001.

C. KD treatment increases ripple interval and frequency, whereas duration is decreased [n = 584/6 (WT), 3971/11 (KO), 1311/11 (KO-KD) events/slices]. Significance determined by an one-way ANOVA followed by Tukey’s multiple comparison test, *p<0.05, **p<0.01, ***p<0.001.

D. Fast ripple intervals are increased and durations are decreased by KD treatment, but internal fast ripple frequencies are unaffected [n = 6130/11 (KO), 1677/11 (KO-KD) events/slices]. Significance determined by an unpaired Student’s t-test, ***p<0.001.