Table 1.

Baseline Characteristics

	All (N=1109)		MAC (N=528)		RIC (N=581)
	N	%	N	%	N	%
Age, median (range)	51 (18, 74)		44 (18, 61)		57 (18, 74)
Patient Sex
Male	658	59.3	289	54.7	369	63.5
Female	451	40.7	239	45.3	212	36.5
Donor Sex
Male	639	57.6	299	56.6	340	58.5
Female	470	42.4	229	43.4	241	41.5
Patinet-Donor Sex
FF	205	18.5	111	21	94	16.2
FM	246	22.2	128	24.2	118	20.3
MF	265	23.9	118	22.3	147	25.3
MM	393	35.4	171	32.4	222	38.2
ECOG PS
0	374	33.7	200	37.9	174	29.9
1	480	43.3	214	40.5	266	45.8
2-3	99	8.9	34	6.4	65	11.1
unknown	156	14.1	80	15.2	76	13.1
Disease
AML	404	36.4	232	43.9	172	29.6
ALL	100	9	85	16.1	15	2.6
CLL	102	9.2	19	3.6	83	14.3
CML	78	7	61	11.6	17	2.9
Hodgkin lymphoma	50	4.5	8	1.5	42	7.2
Multiple Myeloma	35	3.2	1	0.2	34	5.9
MDS	130	11.7	50	9.5	80	13.8
Myeloproliperative Neoplasms	25	2.4	7	1.3	19	3.3
Non-Hodgkin lymphoma	180	16.2	62	11.7	118	20.3
Other Acute Leukemia	4	0.4	3	0.6	1	0.2
HLA Type
Matched/Unrelated	565	50.9	245	46.4	320	55.1
Matched/Related	450	40.6	235	44.5	215	37
Mismatched/Unrelated	86	7.8	42	8	44	7.6
Mismatched/Related	8	0.7	6	1.1	2	0.3
Graft Source
Bone Marrow	70	6.4	54	10.3	16	2.8
PBSC	1039	93.7	474	89.8	565	97.2
Disease Risk Indexa
0: Low	177	16	57	10.8	120	20.7
1: Intermediate	591	53.3	278	52.7	313	53.9
2: High	304	27.4	171	32.4	133	22.9
3: Very high	37	3.3	22	4.2	15	2.6
Patient or Donor CMV seropositivity
No	421	38	216	40.9	205	35.3
Yes	688	62	312	59.1	376	64.7
aGVHD prophylaxis
CI+Sirolimus	697	62.8	288	54.5	409	70.4
CI+Other	376	33.9	229	43.4	147	25.3
Sirolimus+MMF	15	1.4			15	2.6
Ex vivo TCD/Other	21	1.9	11	2.1	10	1.7
Year of HCT, median (range)	2005 (2003, 2009)		2005 (2003, 2009)		2005 (2003, 2009)
CD34 cells/kg (×106), medain (range)	7.8 (0.3, 47.7)		7.7 (0.3, 32.7)		7.9 (0.8, 47.7)
no. of missing CD34	5	0.5	3	0.6	2	0.3
Day 30 Chimerismb, median (range)					90 (0, 100)
no. of missing chimerism					9	1.5
Years of follow-up for survivors     median (range)	5.1 (1.1, 9.6)		5.9 (2.0, 9.2)		5.0 (1.1, 9.6)

^aArmand et al, Blood, 2012;

^bpatients with reduced intensity conditioning only. CI: Calcineurin Inhibitor; TCD: T cell depletion.