Table 4.

Multivariable Cox models^a

	OS				PFS				NRM				Relapse
	HR	95% CI		p-value	HR	95% CI		p-value	HR	95% CI		p-value	HR	95% CI		p-value
Ageb	1.27	1.08	1.49	0.005	1.11	0.95	1.30	0.19	1.34	1.02	1.76	0.036	0.99	0.82	1.20	0.93
Patient-Donor Sex
M<-F vs. Other	1.08	0.90	1.30	0.39	1.03	0.86	1.23	0.76	1.10	0.82	1.49	0.53	1.00	0.81	1.25	0.98
HLA type
MUD vs MRD	1.06	0.90	1.27	0.48	0.98	0.83	1.15	0.78	1.65	1.22	2.22	0.001	0.77	0.63	0.93	0.008
Mismatched vs MRD	1.26	0.94	1.68	0.12	1.08	0.82	1.43	0.59	1.95	1.25	3.03	0.003	0.80	0.55	1.15	0.23
Patient or Donor CMV
seropositivity: Y vs. N	1.06	0.90	1.25	0.47	1.02	0.87	1.19	0.83	1.14	0.87	1.51	0.34	0.97	0.80	1.17	0.73
Disease Relapse Index
Intermediate vs. Low	1.73	1.32	2.26	<.0001	1.93	1.50	2.49	<.0001	1.12	0.76	1.66	0.56	2.50	1.78	3.52	<.0001
High/Very high vs. Low	2.68	2.02	3.56	<.0001	2.98	2.28	3.89	<.0001	1.22	0.79	1.88	0.37	4.61	3.24	6.56	<.0001
Year of Transplantation	0.97	0.93	1.02	0.28	0.95	0.91	1.00	0.03	0.98	0.91	1.07	0.69	0.94	0.89	1.00	0.04
CD34 cells/kg (×106)c
<=4 vs <4-15	1.28	0.99	1.66	0.06	1.31	1.03	1.66	0.03	1.37	0.90	2.09	0.15	1.21	0.91	1.63	0.19
>15 vs <4-15	1.20	0.94	1.53	0.15	1.17	0.93	1.49	0.19	0.83	0.53	1.32	0.43	1.33	1.01	1.76	0.045
ECOG performance Status
1 vs. 0	1.31	1.07	1.58	0.007	1.29	1.07	1.54	0.007	1.21	0.89	1.66	0.23	1.32	1.05	1.65	0.017
2-3 vs. 0	1.58	1.18	2.11	0.002	1.42	1.08	1.88	0.01	1.89	1.19	3.00	0.007	1.26	0.89	1.79	0.20
missing vs. 0	1.29	0.99	1.67	0.06	1.23	0.96	1.58	0.10	1.08	0.69	1.67	0.75	1.31	0.96	1.78	0.09
Graft Source
BM vs. PBSC	0.77	0.51	1.15	0.19	0.81	0.56	1.19	0.29	0.58	0.31	1.07	0.08	1.02	0.63	1.66	0.94
Grade 2-4 aGVHD	1.50	1.26	1.78	<.0001	1.19	1.00	1.42	0.05	2.28	1.75	2.98	<.0001	0.74	0.57	0.96	0.02
Gr. ≥3 Infection within D100	1.89	1.57	2.27	<.0001	1.71	1.40	2.08	<.0001	3.39	2.45	4.70	<.0001	1.14	0.88	1.48	0.33
WBC risk group
1 vs. 0	1.64	1.26	2.13	0.0002	1.49	1.16	1.92	0.0017	2.04	1.34	3.11	0.0009	1.27	0.93	1.74	0.13
2 vs. 0	3.06	2.36	3.97	<.0001	2.88	2.23	3.73	<.0001	3.23	2.15	4.85	<.0001	2.86	2.03	4.03	<.0001

^astratified by conditioning intensity.

^bdichotomized as 1 if age>=40 in MAC or >=60 in RIC; 0 otherwise.

^c5 missing CD34 are combined with CD34<=4 because of a similar hazard ratio.

d: time dependent variable. MUD: matched unrelated donor; MRD: matched related donor.