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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Circ Heart Fail. 2014 Feb 13;7(3):479–490. doi: 10.1161/CIRCHEARTFAILURE.113.000713

Figure 2. Pressure overload in Murf1−/− mice causes myocardial apoptosis, cardiac fibrosis, and cardiac dysfunction after TAC.

Figure 2

A, Lung weight/TL in Murf1−/− and NTg mice 2 and 4 weeks after TAC. # P<0.05 compared to sham-operated mice with the same genotype, * P<0.05 (N=4–8). B, Statistical analysis of echocardiographically measured LV ejection fraction (LVEF) is shown. # P<0.05 compared to sham-operated mice with the same genotype, * P<0.05 (N=5–7). C, Left: Representative images of TUNEL staining of cardiac sections 2 weeks after TAC. Right: Percent TUNEL-positive myocytes. * P<0.05 (N=3). D, Left: Masson’s Trichrome (MT) staining of cardiac sections 2 weeks after TAC. Right: Percentage of area that is MT-positive. * P<0.05 (N=4).