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Classes of Sortases along with substrates and nucleophiles.
| Sortase Class | Substrates | Substrate Motif | Nucleophile |
|---|---|---|---|
| A (housekeeping) | Surface proteins | LPXTG | Lipid II |
| B | Heme transporter | N(P/A)(Q/K)(T/S)(N/S) | Peptidoglycan crossbridge |
| C | Pilin subunits | (I/L)(P/A)XTG | Lys of Pilin |
| D | Mother cell and endospore envelope protein | LPNTA | Lipid II |
