Table 1.
Demographic differences by diagnostic cohort
| Variable | Remitted (N=47) | Relapsed (N=18) | Nonremitted (N=27) | Never depressed (N=70) | Test value | p value |
|---|---|---|---|---|---|---|
| Age | 69.3 (6.5) | 70.0 (6.1) | 72.1 (7.3) | 69.7 (6.2) | F 3,158 = 1.19 | 0.3154 |
| Sex | 59.6 (28) | 66.7 (12) | 55.6 (15) | 81.4 (57) | χ2 = 9.36 | 0.0249 |
| Race | 83.0 (39) | 88.9 (16) | 85.2 (23) | 88.6 (62) | Fisher’s exact | 0.8550 |
| Education | 14.5 (2.2) | 13.9 (3.2) | 14.6 (2.1) | 15.6 (1.6) | F 3,158 = 4.50 | 0.0047 |
| MADRS, baseline | 26.5 (7.4) | 25.0 (7.7) | 26.0 (5.4) | - | F 2,89 = 0.29 | 0.7477 |
| MADRS, 2y | 3.2 (3.3) | 13.8 (12.0) | 18.1 (8.4) | - | F 2,89 = 36.44 | < 0.0001 |
| MMSE, baseline | 28.7 (1.2) | 28.6 (2.0) | 28.4 (1.7) | 28.7 (1.7) | F 3,158 = 0.23 | 0.8771 |
| MMSE, 2y | 28.7 (2.0) | 28.2 (2.9) | 28.3 (2.0) | 28.7 (1.3) | F 3,142 = 0.76 | 0.5200 |
| WMH volume, baseline | 6.9 (9.3) | 3.7 (2.2) | 6.2 (7.4) | 4.9 (5.4) | F 3,158 = 1.28 | 0.2844 |
| WMH volume, 2y | 7.7 (10.5) | 5.1 (3.5) | 8.7 (10.9) | 6.1 (7.9) | F 3,158 = 0.93 | 0.4287 |
Demographic data for the cohort of subjects included in two-year analyses. Data for continuous variables presented as mean (SD) and analyzed with ANOVA with degrees of freedom presented with the F values in the table. Categorical variables are presented as % (N) and analyzed through chi-square tests with 3 degrees of freedom. Analyses included all subjects except the 2-year MMSE, where missing data resulted in a sample of 146 individuals. Age and education presented in years, sex as % female, and race as % white. MADRS = Montgomery-Asberg Depression Rating Scale; MMSE = Mini-Mental State Exam; WMH volume = white matter hyperintensity volume, in milliliters.