. Author manuscript; available in PMC: 2015 Dec 1.

Published in final edited form as: Am J Geriatr Psychiatry. 2013 Nov 22;22(12):1504–1512. doi: 10.1016/j.jagp.2013.11.004

Table 4.

Models predicting longitudinal relationship between hippocampus volume and MADRS score

Variable	F value	p value
Hippocampus Volume	F _1,5603 = 18.03	< 0.0001
Cerebral volume	F _1,5603 = 0.99	0.3206
WMH volume	F _1,5603 = 0.05	0.8183
Baseline MADRS	F _1,5603 = 0.03	0.8664
Sex	F _1,5603 = 0.76	0.6362
Age	F _1,5603 = 0.76	0.3823
Education	F _1,5603 = 0.02	0.8865
Time	F _1,5603 = 7.42	0.0065
Hemisphere	F _1,5603 = 0.29	0.5876
Hippocampus * Time interaction	F _1,5603 = 24.68	< 0.0001

This repeated measure mixed model analysis includes 152 depressed elders who had hippocampal volume measures at any time during their study participation. This analysis includes the 92 depressed participants included in the previous analyses detailed in Tables 1–3. Time refers to time in the study; hemisphere refers to right or left hippocampus. WMH = white matter hyperintensity volume. MADRS = Montgomery-Asberg Depression Rating Scale.