TABLE II.
Effect of Donor KIR Genotype on Outcome
A. All Transplants | LFS | ||
---|---|---|---|
Donor KIR Content Group | N | RR (CI) | P |
KIR B=0 [i.e. KIR A/A] | 478 | 1.00 | |
KIR B ≥1 [i.e. KIR B/x] | 964 | 0.89 (0.78–1.01) | 0.075 |
KIR B=1 | 535 | 0.98 (0.85–1.14) | 0.80 |
KIR B=2 | 325 | 0.79 (0.66–0.94) | 0.008 |
KIR B=3+4 | 104 | 0.76 (0.59–0.99) | 0.043 |
KIR B=0 or 1 [i.e. Neutral Donors] | 1013 | 1.00 | |
B≥2 (non Cen B/B) [i.e. Better Donors] | 290 | 0.86 (0.73–1.00) | 0.055 |
B≥2 (Cen B/B) [i.e. Best Donors] | 139 | 0.67 (0.54–0.85) | 0.0007 |
B≥2 [i.e. Better/Best Donors] | 429 | 0.79 (0.69–0.91) | 0.001 |
B. All Transplants | Relapse | ||
---|---|---|---|
Donor KIR B Content Group | N | RR (CI) | P |
KIR B=0 [i.e. KIR A/A] | 499 | 1.00 | |
KIR B ≥1 [i.e. KIR B/x] | 1003 | 0.88 (0.73–1.06) | 0.18 |
KIR B=1 | 556 | 1.03 (0.84–1.26) | 0.77 |
KIR B=2 | 339 | 0.73 (0.57–0.94) | 0.014 |
KIR B=3+4 | 108 | 0.64 (0.43–0.97) | 0.033 |
KIR B=0 or 1 [i.e. Neutral Donors] | 1055 | 1.00 | |
B≥2 (non Cen B/B) [i.e. Better Donors] | 302 | 0.82 (0.65–1.02) | 0.078 |
B≥2 (Cen B/B) [i.e. Best Donors] | 145 | 0.46 (0.31–0.68) | 0.0001 |
B≥2 [i.e. Better/Best Donors] | 447 | 0.70 (0.57–0.86) | 0.0005 |