Table III.
Outcome | Donor KIR Group | All Transplants | HLA-Matched | HLA-Mismatched | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
N | RR | P | N | RR | P | N | RR | P | |||
Recipient HLA C1/x | LFS | KIR-Neutral | 865 | 1.00 | 502 | 1.00 | 363 | 1.00 | |||
KIR-Better/Best | 354 | 0.78 (0.67–0.91) | 0.0015 | 201 | 0.86 (0.69–1.07) | 0.17 | 153 | 0.70 (0.56–0.88) | 0.003 | ||
Relapse | KIR-Neutral | 903 | 1.00 | 521 | 1.00 | 382 | 1.00 | ||||
KIR-Better/Best | 367 | 0.70 (0.56–0.87) | 0.0018 | 211 | 0.79(0.59–1.06) | 0.11 | 156 | 0.61 (0.43–0.88) | 0.008 | ||
TRM | KIR-Neutral | 893 | 1.00 | 516 | 1.00 | 377 | 1.00 | ||||
KIR-Better/Best | 363 | 0.89 (0.72–1.09) | 0.26 | 207 | 1.02 (0.75–1.40) | 0.90 | 156 | 0.82 (0.62–1.10) | 0.19 | ||
Recipient HLA C2/C2 | LFS | KIR-Neutral | 148 | 1.00 | 77 | 1.00 | 71 | 1.00 | |||
KIR-Better/Best | 75 | 0.93 (0.63–1.37) | 0.71 | 42 | 0.81 (0.45–1.43) | 0.47 | 33 | 1.28 (0.67–2.45) | 0.45 | ||
Relapse | KIR-Neutral | 152 | 1.00 | 80 | 1.00 | 72 | 1.00 | ||||
KIR-Better/Best | 80 | 0.80 (0.47–1.36) | 0.41 | 43 | 0.64 (0.29–1.42) | 0.27 | 37 | 1.20 (0.51–2.83) | 0.68 | ||
TRM | KIR-Neutral | 150 | 1.00 | 79 | 1.00 | 71 | 1.00 | ||||
KIR-Better/Best | 78 | 0.94 (0.57–1.55) | 0.81 | 42 | 0.89 (0.42–1.89) | 0.76 | 37 | 0.98 (0.45–2.16) | 0.96 |