Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
miRISC assembly in human cells. a The first step is miRISC loading, when the miRNA/miRNA* duplex is transferred from Dicer to Ago in the miRISC loading complex (RLC). b Next, domain N of Ago actively wedges between miRNA strands and c the PAZ domain of Ago unwinds the miRNA duplex. d The passenger strand is removed from miRISC and undergoes rapid degradation. e miRNA within mature miRISC binds with imperfect complementarity to its target sites. See text for more details
