Table 3.

UGT1A7 and UGT1A9 polymorphisms

	N129K (P < 0.01)			Allele frequency of UGT1A7 N129K
	T/T	T/G	G/G
Uzbekistan	18 (19, 12–28)	46 (47, 38–57)	33 (34, 25–44)	0.58
Japan	63 (42, 34–50)	67 (45, 37–53)	20 (13, 9–20)	0.36
P value	<0.01	0.696	<0.01

	W208R (P = 0.149)			Allele frequency of UGT1A7 W208R
	T/T	T/C	C/C
Uzbekistan	47 (48, 39–58)	37 (38, 29–48)	13 (13, 8–22)	0.32
Japan	86 (57, 49–65)	54 (36, 29–44)	10 (7, 4–12)	0.25
P value	0.192	0.788	0.115

	UGT1A7*2 or *3 (P < 0.01)
	*1/*1	*1/*2	*1/*3(*2/*4)	*2/*2	*2/*3	*3/*3
Uzbekistan	18 (19, 12–28)	24 (25, 17–34)	22 (23, 15–32)	5 (5, 2–12)	15 (15, 9–24)	13 (13, 8–22)
Japan	63 (42, 34–50)	22 (15, 10–21)	45 (30, 23–38)	1 (1, 0–4)	9 (6, 3–11)	10 (7, 4–12)
P value	<0.01	0.065	0.242	0.036	0.026	0.115

	UGT1A7*12 (P = 0.149)			Allele frequency of UGT1A7*12
	T/T	T/G	G/G
Uzbekistan	47 (48, 39–58)	37 (38, 29–48)	13 (13, 8–22)	0.32
Japan	86 (57, 49–65)	54 (36, 29–44)	10 (7, 4–12)	0.25
P value	0.192	0.788	0.115

	UGT1A9*22 (P < 0.01)			Allele frequency of UGT1A9*22
	T9/T9	T9/T10	T10/T10
Uzbekistan	31 (32, 23–42)	47 (49, 39–58)	19 (20, 13–29)	0.44
Japan	16 (11, 7–17)	69 (46, 38–54)	65 (43, 36–51)	0.66
P value	<0.01	0794	<0.01

For each genotype, the values represent the number of subjects (percentage of subjects, 95 % CI). The occurrence of N129 alone is termed UGT1A7*2, and the occurrence of W208 alone is termed UGT1A7*4, whereas co-occurrence of N129K and W208R is termed UGT1A7*3. In the case of heterozygous N129K and heterozygous W208R, the possible genotypes are UGT1A7*1/*3 and *2/*4; however, because UGT1A7*4 is known to be quite rare in non-Uzbek populations, the statistical analysis was performed on the assumption that all the genotypes were UGT1A7*1/*3