Table 4.
Allele frequency of UGT1A polymorphisms in different ethnic groups
| Origin | ||||||
|---|---|---|---|---|---|---|
| Africa | Europe | Uzbekistan | India | East Asia | Japan | |
| Reference | 23–25, 32, 41 | 7, 8, 17, 23–25, 28, 32, 35, 36, 41 | Present study | 24, 30, 31, 40 | 27, 29, 31, 32, 38, 39 | 5, 6, 9, 12, 13, 21, 25, 26, 33, 34, 37 |
| UGT1A1*6 | 0 | 0.007–0.01 | 0.09 | 0.066–0.16 | 0.13–0.24 | 0.14–0.23 |
| UGT1A1*27 | 0 | 0 | 0.005 | 0 | 0.015–0.02 | 0.003 |
| UGT1A1*28 | 0.26–0.4 | 0.23–0.38 | 0.31 | 0.28–0.41 | 0.07–0.17 | 0.04–0.14 |
| UGT1A1*60 | 0.85 | 0.44–0.62 | 0.5 | 0.43 | 0.235–0.34 | 0.23–0.26 |
| UGT1A1*93 | 0.29 | 0.23–0.35 | 0.3 | 0.35 | 0.12 | 0.12 |
| UGT1A7*1 | 0.38 | 0.34–0.43 | 0.422 | 0.26 | 0.58–0.63 | 0.59–0.65 |
| UGT1A7*2 | 0.39 | 0.24–0.28 | 0.252 | 0.36 | 0.22–0.27 | 0.1–0.14 |
| UGT1A7*3 | 0.23 | 0.31–0.35 | 0.325 | 0.36 | 0.15 | 0.21–0.29 |
| UGT1A7*4 | 0.01 | 0–0.019 | 0 | 0.032 | 0 | 0–0.03 |
| UGT1A9*22 | 0.44 | 0.39–0.41 | 0.44 | – | 0.42 | 0.6–0.66 |
Different ethnic groups have different allele frequencies of UGT1A polymorphisms. Note that individual cohorts contributing to the ethnic group data comprised healthy volunteers or cancer patients or both. Europe includes individuals from several different European countries and Caucasians from non-European countries. East Asia includes China and Korea. All allele frequencies obtained from our previous study of the Japanese population are within the range of reported studies (Tables 2, 3)