Figure 4.
Comparison of the interaction of MTX-Cmpd2.1 and MTX-Cmpd2.2 with a known kinase target of compound 2. LEU2 reporter activation growth assay with yeast expressing a TgCDPK1-AD fusion protein in the presence of MTX-Cmpd2.1 and MTX-Cpmd2.2. Growth was assessed at (A) 48 hour and (B) 96 hour by measuring the OD600 of the yeast culture. Samples treated with the DMSO vehicle were used as negative controls. Mean values ± SD are shown (n = 3).
