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. Author manuscript; available in PMC: 2014 May 23.
Published in final edited form as: Biochem Biophys Res Commun. 2013 Mar 21;434(4):705–709. doi: 10.1016/j.bbrc.2013.03.032

Fig. 4.

Fig. 4

Long-term treatment with functional acid sphingomyelinase inhibitors or genetic heterozygosity protects cystic fibrosis mice from lung inflammation. Concentrations of IL-1 and KC are elevated in lungs of untreated, 8 month-old Cftr-deficient mice. Levels of these inflammatory markers are corrected by long-term treatment with amitriptyline or fluoxetine or heterozygosity of acid sphingomyelinase. IL-1 and KC levels were measured in lung homogenates by ELISA. Displayed is the mean ± SD from each 5 mice, ***p < 0.001 compared as indicated.