TABLE I.
Investigator | Porous Material | Optimal Pore Size (μm) | Application and Test Subject | EHiration of Investigation |
---|---|---|---|---|
Brauker et al.19 | PTFE | 5 | Membrane implanted in rat subcutis | 3 weeks |
Sharkawy et al.21 | PVA | 60 | Membrane implanted in rat subcutis | 12–16 weeks |
Ward et al.24 | ePTFE and PVA | ePTFE: 1 PVA: ~47 |
Membrane implanted in rat subcutis | 7 weeks |
Marshall et al.25 | HEMA hydrogels | 35 | Hydrogel implanted in mouse subcutis | 4 weeks |
Updike et al.23 | ePTFE | 5–1026 | Glucose sensor implanted in dog subcutis | 162 daysa (best of six sensors) |
Yu et al.27 | Epoxy-enhanced polyurethane | Not specified | Glucose sensor implanted in rat subcutis | 56 daysa (best of cose sensors) |
Gilligan et al.28 | ePTFE | Not specified | Glucose sensor implanted in human subcutis | 185 daysa (best of five sensors) |
ePTFE, expanded polytetrafluoroethylene; PVA, polyvinyl alcohol; HEMA, hydroxyethyl methacrylate.
Maximum time sensor remained functional in vivo.