Skip to main content
. Author manuscript; available in PMC: 2015 Mar 20.
Published in final edited form as: Mol Cell. 2014 Mar 20;53(6):979–992. doi: 10.1016/j.molcel.2014.02.032

Figure 7. Model in which H3K4 methylation state dictates recruitment of ING1 and Sin3A to chromatin.

Figure 7

H3K4me1 covers the promoters of a subset of repressed, but inducible, genes. MLL3/4-mediated H3K4me1 is necessary for gene repression. Gene activation coincides with a change in H3K4me1 levels and loss of MLL3/4. On some genes, MLL3/4 are replaced with a distinct COMPASS complex (Set1a or MLL1) able to tri-methylate H3K4 on chromatin linked to the TSS. Although H3K4me3 is necessary for ING1 and Sin3A recruitment, H3K4me1 at the same promoters might restrict the localization of ING1 and Sin3A. Alterations in the ratio of H3K4me1 and H3K4me3 on active genes lead to loss of Sin3A recruitment to chromatin and repression. Multi-valent interaction with sequence-specific factors also contributes to Sin3 recruitment (omitted for simplicity). See text for details.