FIGURE 3.

Models for Iztli peptides internalization on yeast cells. A, the model assuming an endocytic import of Iztli peptide via Ste2p (× denotes degradation). B, the model assuming permeation of Iztli peptide where the peptide may cross the membrane independent of Ste2p-mediated endocytosis. C, comparison of the two models fitted to the measured colony-forming unit time course of dead cells (n = 8, bars denote S.D.). The model assuming direct import generally performed better, noticeable for early time points. Mio, millions of cells.