Skip to main content
. 2014 Apr 4;289(21):14583–14599. doi: 10.1074/jbc.M114.560573

FIGURE 5.

FIGURE 5.

The VIP derivatives improve survival and bacterial clearance in sepsis. A, survival of mice subjected to sepsis by CLP and treated with vehicle (control) or with VIP, VIP51, and VIP51(6–30) (n = 20 mice/group). B and C, bacterial load (B, n = 10 mice/group) and cytokine contents (C, n = 5 mice/group) were determined in sera and peritoneal fluids isolated 24 h after sepsis induction. The mean ± S.E. (error bars) (n = 4, each performed in duplicate) is shown. n.d, not detectable. *, p < 0.05; **, p < 0.001 versus untreated control mice. D, histological sections of lungs isolated 24 h after CLP induction. Images are representative of 10 mice/group. Scale bar, 100 μm.