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. 2014 Apr 8;289(21):14612–14623. doi: 10.1074/jbc.M114.548230

FIGURE 2.

FIGURE 2.

Stabilizing WNT1 G-quadruplex structure by BMVC and BMVC4. A, structures of G-quadruplex stabilizers BMVC and BMVC4. B, BMVC and BMVC4 enhance the T1a of WNT1 G-quadruplex. Temperature-dependent CD signals at 265 nm of the WNT1 quadruplex and upon interaction with BMVC and BMVC4 in 5 mm K+ solution at 8 μm DNA concentration with 16 μm BMVC or BMVC4. C, CD and induced CD spectra of 100 μm Wnt1 oligonucleotide in 5 mm K+ buffer solution with the addition of BMVC from 1:1 to 1:3 molar ratio. D, CD and induced CD spectra of 100 μm Wnt1 oligonucleotide in 5 mm K+ buffer solution with the addition of BMVC4 from 1:1 to 1:3 molar ratio.