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Characterization of the Merlin-FERM/DCAF1 interaction. A, domain organizations of Merlin and DCAF1 are shown as schemes. The Merlin-FERM/DCAF1-FBD interaction is indicated by a double-headed arrow. B--G, ITC-based measurements showing the binding affinities between DCAF1-CT and Merlin-FERM (B), and between DCAF1-FBD and Merlin-FERM (C), Moesin-FERM (D), Merlin-FERMF3/Moesin (E), Merlin-FL (F), and Merlin-FLS518D (G).
