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Schematic of the nuclear selenoprotein mRNPs assembly. Recoding factors are imported into the nucleus to assemble with selenoprotein mRNAs as described in Refs. 40, 50, 53. mRNPs are built and exported to the cytoplasm to promote efficient translation by the ribosome. An increase in nucleocytoplasmic shuttling in response to H2O2 induced oxidative stress is proposed to improve selenocysteine insertion complex nuclear assembly and, consequently, selenoprotein expression.
