TABLE 2.
Hematological examination reveals Nmnat3gt/gt mice are anemic, but not pancytopenia
Peripheral blood cell numbers and various hematological parameters were counted in 12-week-old WT and Nmnat3gt/gt mice (n = 4 for each group). All data are expressed as mean ± S.D. The abbreviations used are as follows: RBC, red blood cell; Hb, hemoglobin; HCT, hematocrit; MCV, mean corpuscle volume; MCH, mean corpuscle hemoglobin; MCHC, mean corpuscle hemoglobin concentration; WBC, white blood cell; Neu, neutrophil; Lym, lymphocyte; Ba, basophil; Eo, eosinophil; Mo, monocyte; PLT, platelet.
| Peripheral blood cell count |
|||
|---|---|---|---|
| WT | Nmnat3gt/gt | p value | |
| RBC (×104/μl) | 730 ± 12.2 | 483 ± 11.8 | <0.0001 |
| Hb (g/dl) | 11.2 ± 0.299 | 7.70 ± 0.141 | <0.0001 |
| Ht (%) | 37.0 ± 0.825 | 25.4 ± 0.480 | <0.0001 |
| MCV (fl) | 50.7 ± 0.804 | 52.6 ± 0.545 | <0.05 |
| MCH (pg) | 15.4 ± 0.258 | 16.0 ± 0.206 | <0.05 |
| MCHC (%) | 30.4 ± 0.311 | 30.4 ± 0.386 | NSa |
| WBC (×102/μl) | 24.3 ± 5.44 | 16.8 ± 5.68 | NS |
| Neu (%) | 17.3 ± 3.40 | 13.0 ± 3.56 | NS |
| Lym (%) | 78.0 ± 5.29 | 84.5 ± 3.79 | NS |
| Ba (%) | 0.00 ± 0.00 | 0.00 ± 0.00 | NS |
| Eo (%) | 2.00 ± 1.83 | 1.00 ± 0.82 | NS |
| Mo (%) | 2.75 ± 0.96 | 1.50 ± 1.29 | NS |
| PLT (×104/μl) | 87.3 ± 7.83 | 76.2 ± 2.62 | NS |
| Reticulocyte (‰) | 36.0 ± 1.41 | 236 ± 10.2 | <0.0001 |
a NS, not significant.