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. 2014 Apr 9;289(21):15130–15140. doi: 10.1074/jbc.M113.525576

FIGURE 2.

FIGURE 2.

Sequence alignments of Alv-a1-pHCl and Alv-a9 with their closest homologues. Alignment of Alv-a1-pHCl with the glutamate-gated ion channel of C. elegans and human glycine α1 (A) and Alv-a9 with the human α9 sequence (B). The construct tAlv-a1-pHCl is N-terminally truncated before Ser-65 (green, boxed). The M3-M4 loop is marked in pink. Secondary structure elements are indicated by bars. An alignment with all members of the CLR family is given in supplemental Fig. 1A.