TABLE 2. Summary of the Effect of Brominated and Chlorinated Dioxins and Furans on Gene Expression.

	TCDD	1PeBDF	1PeCDF	4PeBDF	4PeCDF	TBDF	TCDF	DBDCDD	TriBDD
Dose range (μg/kg)
	0.1–3	3–90	3–90	3–90	3–90	3–90	3–90	0.1–3	1–30
Gene
Phase I XMEs
Cyp1a1	↑≥0.1	↑≥3	↑≥9	↑≥3	↑≥3	↑ ≥3	↑≥3	↑≥0.1	↓3, 10
Cyp1a2	↑≥0.1	↑≥3	↑≥3	↑≥3	↑≥3	↑≥3	↑ ≥3	↑ ≥0.1	–
Phase II XMEs
Ugt1a1	↑3	–	–	↑≥15	↑ ≥30	↑ 90	↓3, 9	↑0.1	–
Ugt1a6	↑3	–	–	↑ 90	–	–	↓3 - 15	↑0.1, 0.5	–
Sult1c	–	–	–	–	–	–	–	–	–
Sult1e	↓ ≥1	↓ ≥15	–	–	–	↓≥30	–	–	–
Phase III XMEs
Abcb1a	–	–	–	–	–	↓3, 15, 30, 90	–	–	–
Abcb1b	↓≥1	–	–	–	–	↓ ≥3	↓≥3	–	–
Abcb4	–	–	–	–	–	–	↓9, 15	↓3	–
Abcc2	–	–	–	–	–	↓≥3	↓3, 15, 30, 90	↓3	–
Abcc3	↑3	–	–	↑≥15	–	–	↓9, ↑90	↑0.1, 3	–
Slco1b	↓3	–	–	–	–	↓ ≥3	↓ 90	↓3	–
Slc22a7	↑3	–	–	–	–	↑ 9, 30	↑3, 30, 90	–	–
Slc16a2	↓3	–	–	↓≥30	–	↓≥9	–	↓3	–
Thyroid Responsive
Ttr	↓≥1	↓ ≥3	–	↓ ≥3	↓≥15	↓≥9	↓≥30	↓ 3	–
Dio1	–	–	–	–	–	↓9, 15, 90	↓ 3, 9, 15, 90	–	–
Housekeeping
Gapdh	–	–	–	–	–	↓≥3	↓ ≥3	–	–
18srRNA	–	–	–	–	–	–	–	↓3	–
ActB	–	↓90	–	–	–	↓ ≥3	↓≥3	↓3	–
Immune
Crip2	↑3	–	–	–	–	↓ ≥9	↓≤15	↓3	–
Ifnγ	–	–	–	↓90	–	↓≥9	↓9, 90	–	–
Il1α	↑0.1, 0.3, 3	–	–	–	–	–	–	↓3	–
Il1β	–	–	–	↓3, 9, 30, 90	–	↓ ≥3	↓3, 9, 30, 90	–	–
Il4	–	–	–	–	–	–	–	↓0.1, 0.5, 1, 3	↓≤3
Il6	–	–	–	↓3, 30, 90	–	↓15, 90	↓≥30	–	–
Il10	–	–	–	–	–	–	–	–	–
Il12β	–	–	–	–	–	–	–	–	–
Nfκb	–	↓15, 90	–	↓≥30	–	↓≥15	↓ 3, 9, 30, 90	↓0.3, 3	↓5, 30
Tnfα	–	–	–	–	–	↓ 9, 15	↓9, 90	↓ ≥1	↓ 3

Note. This table represents a summary of specific chemical treatments with statistically significant effects. The numbers represent the dosage at which effects were observed. See Supplementary table 4A, B, C, and D for RQ values.