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. Author manuscript; available in PMC: 2014 May 23.
Published in final edited form as: J Biomed Inform. 2012 Sep 28;46(2):238–251. doi: 10.1016/j.jbi.2012.09.004

Table 6.

Comparison of Semantics-based techniques for recovering and decomposing Swanson’s Associations

Assoc. 1.1 Prostaglandin (PGE1) → INHIBITS → platelet aggregation → CAUSES → Raynaud Syndrome
Subgraph 73 Eicosapentaenoic Acid DISRUPTS Platelet aggregation Alprostadil DISRUPTS Platelet aggregation Alprostadil INTERACTS_WITH Raynaud Disease
Assoc. 1.2 Prostacyclin (PGI2) → INHIBITS → platelet aggregation → CAUSES → Raynaud Syndrome
Subgraph 77 Eicosapentaenoic Acid DISRUPTS Platelet aggregation Epoprostenol DISRUPTS Platelet aggregation Epoprostenol TREATS Raynaud Disease
Epoprostenol TREATS Raynaud Phenomenon
78
80 Epoprostenol INHIBITS_MAN Platelet aggregation
81
83 Epoprostenol PREVENTS_MAN Platelet aggregation
84
135 Eicosapentaenoic Acid STIMULATES Epoprostenol
150
Assoc. 1.3 Nifedipine → ISA → CCB → INHIBITS → platelet activation → ASSOCIATED WITH → Raynaud Syndrome
Subgraph 91 Eicosapentaenoic Acid DISRUPTS Platelet function Nifedipine DISRUPTS Platelet function Nifedipine TREATS Raynaud Phenomenon
140 Eicosapentaenoic Acid STIMULATES Epoprostenol Epoprostenol TREATS Raynaud Phenomenon
Assoc. 2.1 Prostacyclin (PGI2) → AUGMENTS → Erythrocyte Deformability → INHIBITS → blood viscosity → CAUSES → Raynaud Syndrome (in vitro)
Subgraph 71 Eicosapentaenoic Acid DISRUPTS blood viscosity Ketanserin DISRUPTS blood viscosity Ketanserin TREATS Raynaud Phenomenon
175 Fish Oils AFFECTS blood viscosity
135 Eicosapentaenoic Acid STIMULATES Epoprostenol Epoprostenol TREATS Raynaud Disease
150 Epoprostenol TREATS Raynaud Phenomenon
Assoc. 2.2 Ketanserin → INHIBITS → serotonin → AUGMENTS → Erythrocyte Deformability → INHIBITS → blood viscosity → CAUSES → Raynaud Syndrome
Subgraph 71 Eicosapentaenoic Acid DISRUPTS blood viscosity Ketanserin DISRUPTS blood viscosity Ketanserin TREATS Raynaud Phenomenon
175 Fish Oils AFFECTS blood viscosity
Assoc. 3.1 Prostaglandin (PGE1) → CAUSES → vasodilation → INHIBITS → Raynaud Syndrome
Assoc. 3.2 Prostacyclin (PGI2) → CAUSES → vasodilation → INHIBITS → Raynaud Syndrome
Subgraph 25 Eicosapentaenoic Acid AFFECTS MAN Vascular constriction Epoprostenol INHIBITS_MAN Vascular constriction Epoprostenol TREATS Raynaud Disease
26 Epoprostenol TREATS Raynaud Phenomenon
Assoc. 3.3 Nifedipine → ISA → Calcium Channel Blocker → CAUSES → vasodilation → INHIBITS → Raynaud Syndrome
Subgraph 35 Eicosapentaenoic Acid AFFECTS_MAN Vascular constriction Nifedipine INHIBITS_MAN Vascular constriction Nifedipine TREATS Raynaud Phenomenon