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. Author manuscript; available in PMC: 2014 May 23.
Published in final edited form as: Nature. 2013 Mar 24;496(7444):238–242. doi: 10.1038/nature11986

Fig. 1. Glycolysis is necessary for LPS-induced IL-1β expression.

Fig. 1

(A, B) IL-1β and TNFα mRNA in 100ng/ml LPS- or 1×105 B pertussis- stimulated BMDMs ± 2DG (1mM) pretreatment for 3h (n=3). (C) Mice i.p. injected ± 2DG (2g/kg) or PBS for 3h, then 15 mg/kg LPS or PBS for 1.5h. Serum levels of IL-1β and TNFα (LPS n=15; LPS+2DG n=14; 2DG n=8; vehicle n=5). Error bars, s.e.m, * p < 0.05; ** p < 0.01.