Table 3.
Regimen-related toxicity in 102 patients
| Grade, n (%) |
||||
|---|---|---|---|---|
| Toxicity | Grade I | Grade II | Grade III | Grade IV |
| Liver | ||||
| Transaminase elevation | 6 (6) | 0 (0) | 1 (1) | 0 (0) |
| Bilirubin elevation | 6 (6) | 5 (5) | 2 (2) | 0 (0) |
| VOD* | 0 (0) | 0 (0) | 1 (1) | 0 (0) |
| Alkaline phosphatase elevation | 6 (6) | 0 (0) | 1 (1) | 0 (0) |
| Gastrointestinal tract | ||||
| Diarrhea | 37 (36) | 19 (19) | 5 (5) | 0 (0) |
| Nausea and vomiting | 49 (48) | 30 (29) | 7 (7) | 0 (0) |
| Mucositis | 18 (18) | 50 (49) | 7 (7) | 0 (00 |
| Urinary tract/kidney | ||||
| Creatinine elevation | 2 (2) | 0 (0) | 0 (0) | 0 (0) |
| Hemorrhagic cystitis | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Skin | ||||
| Rash | 7 (7) | 2 (2) | 1 (1) | 0 (0) |
| Neurologic | ||||
| Seizures | 0 (0) | 1 (1) | 0 (0) | 0 (0) |
| Pulmonary/pleural | ||||
| Shortness of breath | 1 (1) | 2 (2) | 0 (0) | 0 (0) |
| Pulmonary infiltrate | 2 (2) | 5 (5) | 0 (0) | 0 (0) |
| Cardiovascular | ||||
| Tachycardia | 1 (1) | 0 (0) | 3 (3) | 0 (0) |
*
VOD; veno-occlusive disease of the liver.