Table 4.
Patient Characteristics, by LID Severity
| LID severity | ||||
|---|---|---|---|---|
| Characteristics | Mild, 39% (N = 67) | Moderate, 31% (N = 53) | Severe, 30% (N = 52) | Total, 100% (N = 172) |
| Sex, N (%) | ||||
| Male | 33 (49) | 23 (43) | 23 (44) | 79 (46) |
| Female | 34 (51) | 30 (57) | 29 (56) | 93 (54) |
| Age, N (%) | ||||
| ≤50 yrs | 2 (3) | 0 (0) | 0 (0) | 2 (1) |
| 51–60 yrs | 8 (12) | 10 (19) | 5 (10) | 23 (13) |
| 61–70 yrs | 43 (64) | 30 (57) | 24 (46) | 97 (56) |
| 71–80 yrs | 14 (21) | 9 (17) | 19 (37) | 42 (24) |
| 81–90 yrs | 0 (0) | 4 (8) | 4 (8) | 8 (5) |
| Mean time from Parkinson's disease diagnosisa to levodopa initiation, yrs | 0.9 | 1.7 | 1.7 | 1.4 |
| Mean total initial daily dose of levodopa, mgb | 250 | 216 | 255 | 241 |
| Mean time from levodopa initiationc to LID onset, yrsb | 4.8 | 4.8 | 6.4 | 5.3 |
| PDQ-39 sum score, mean (SD) | 43 (20) | 75 (14) | 92 (16) | 82 (20) |
| mAIMS, mean (SD) | 10 (10) | 13 (6) | 15 (6) | 14 (6) |
a
Mean date range of Parkinson's disease diagnosis: 1998–2001.
b
Two patients were removed from the analysis of the mild LIDs and the overall analysis because total daily doses of levodopa were recorded in error as 1 mg daily.
c
Mean date range of levodopa initiation: 1999–2002.
LID indicates levodopa-induced dyskinesia; mAIMS, modified Abnormal Involuntary Movement Scale; PDQ-39, 39-item Parkinson's Disease Questionnaire; SD, standard deviation.