Table 5.

Total Annual Costs and Budget Impact: Reference Scenario versus New Scenario

	Reference scenario (standard of care)		New scenario (epigenetic assay)
Cost	Total annual cost, $	PMPM cost, $	Total annual cost, $	PMPM cost, $
Total cost of epigenetic assay	0	0	1,623,143	0.14
Total cost of repeated biopsies	2,864,142	0.33	710,198	0.06
Total cost of repeated biopsies avoided	0	0	2,152,276	0.18
Total diagnostic cost to health plan	2,864,142	0.24	2,333,341	0.19
Total diagnostic cost per patient	3172	0.24	2584	0.19
Total budget impact to plan			−530,801
Total budget impact to plan PMPM				−0.442

PMPM indicates per member per month.