Table 6.

Sensitivity Analysis: Total Costs and Budget Impact

	Reference scenario (standard of care)		New scenario (epigenetic assay)
Cost	Total annual cost, $	PMPM cost, $	Total annual cost, $	PMPM cost, $
Total cost of epigenetic assay	0	0.00	5,346,168	0.53
Total cost of repeated biopsies	9,429,097	1.09	2,342,681	0.27
Total cost of repeated biopsies avoided	0	0.00	7,086,416	0.82
Total diagnostic cost to health plan	9,429,097	1.09	7,688,849	0.81
Total diagnostic cost per patient	3172	0.33	2584	0.24
Total budget impact to plan			−1,740,248
Total budget impact to plan PMPM				−0.1450

PMPM indicates per member per month.