Table 2.
BLOOM, BLOSSOM, and BLOOM-DM: Evaluating Lorcaserin HCl as an Adjunct to Diet and Lifestyle Modification for Weight Loss
| Clinical trial | Medication | Method | Patients, N | P Value | Side effects | Comments |
|---|---|---|---|---|---|---|
| BLOOM | Lorcaserin HCl | 10 mg twice daily vs placebo (both with diet and exercise) | 3182 | <.001 | Headache, nausea, back pain, nasopharyngitis | 47.5% vs 20.3% achieving ≥5% total body weight loss |
| BLOSSOM | Lorcaserin HCl | 10 mg twice daily vs 10 mg daily vs placebo (with diet and exercise) | 4008 | <.001 | Headache, nausea, dizziness, fatigue, upper respiratory infection | 47.2% vs 40.2% vs 25% achieving ≥5% total body weight loss |
| BLOOM-DM | Lorcaserin HCl | 10 mg twice daily vs 10 mg daily vs placebo (all with diet and exercise) All patients with type 2 diabetes |
604 | <.001 | Headache, nausea, back pain, nasopharyngitis, symptomatic hypoglycemia | 37.5% vs 44.7% vs 16.1% achieving ≥5% total body weight loss |