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. Author manuscript; available in PMC: 2014 May 23.
Published in final edited form as: Nature. 2013 Nov 13;503(7476):365–370. doi: 10.1038/nature12790

Figure 2. ADEP4 kills persisters and in combination with rifampicin or linezolid eradicates stationary phase S. aureus.

Figure 2

a, ADEP4 kills persisters isolated following ciprofloxacin treatment. b, Conventional antibiotics are inactive against stationary phase S. aureus. c, ADEP4 activity against stationary S. aureus. d, ADEP4 in combination with rifampicin or linezolid eradicates stationary phase S. aureus to the detection limit in 72h in MHB and e, 24h in chemically defined media. f, ADEP4 resistant mutants are less tolerant to rifampicin and linezolid than the parent wild type strain. The X axis is the limit of detection.* represents eradication to the limit of detection.