Table 1.
Time goals | Ventilatory goals |
a. Δtª - first clinical assessment: graphical complementary test <6 hours | a. PEEP = 8-10 cmH2O (t1) |
b. Δtb - first clinical assessment: recovery <24 hours | b. Tidal volume = 5-8 mL/kg (t1) |
c. Fulfillment of all time goals | c. Plateau pressure <30 cm H2O (t1) |
d. PaO2/FiO2 >300 (t1) | |
Temperature goals | e. Fulfillment of all ventilatory goals |
a. Measurement of central temperature | e'. Fulfillment of goals without PaO2/FiO2 |
b. Temperature > 35 ºC (t0) | |
c. Temperature > 35 ºC (t1) | Endocrine-metabolic goals |
d. Fulfillment of all temperature goals | a. Methylprednisolone 15 mg/kg every 24 hours |
b. Levothyroxine 300 μ g every 24 hours per enteral route | |
Hemodynamic goals | c. Glucose <180 mg% (t1) |
a. PAM >65 mm Hg (t1) | d. Insulin IV when glycemia >180 mg/dL |
b. Urine output >0.5 mL/kg/h and < 4 mL/kg/h (t1) | e. Na+ from 130-150 mEq/L (t1) |
c. Fulfillment of all hemodynamic goals | f. Fulfillment of all hormone replacement goals |
Physiological variables | Outcome indicators |
a. pH, base excess, PaO2/FiO2 (t0 e t1) | a. Losses due to cardiac arrest |
b. Heart rate, MAP (t0 and t1) | b. Actual donation |
c. Fluid infusion, vasopressor agents, urine output, and fluid balance (t0 e t1) | c. Transplanted organs/donor |
d. Glycemia (t0 and t1) | d. Losses due to family refusal |
e. Lactate, hematocrit, sodium, and creatinine (t1) | e. Losses due to medical contraindication |
t0 - time of the first clinical assessment; t1 - immediately before recovery; MAP - mean arterial pressure; PEEP - positive end-expiratory pressure; PaO2/FiO2 - partial pressure of oxygen/fraction of inspired oxygen; IV - per intravenous route.