Table 2.
Characteristics | Phase 1 | Phase 2 | p value | |
(N = 18) | (N=24) | |||
Male gender | 11 (61.1) | 16 (64) | 0.71 | |
Age (years) | 39.4±15 | 49.8±19.6 | 0.07 | |
Cause of brain death | ||||
Brain trauma | 9 (50) | 8 (32) | 0.27 | |
Stroke | 6 (33.3) | 14 (60) | 0.21 | |
Other | 3 (16.6) | 2 (8) | 0.41 | |
Temperature (ºC) | ||||
t0 | 36.4±1.1 | 36.3±1.6 | 0.83 | |
t1 | 36.4±0.9 | 36.8±0.7 | 0.17 | |
HR (bpm) | ||||
t0 | 107±25 | 106±27 | 0.83 | |
t1 | 104±28 | 106±23 | 0.82 | |
MAP (mmHg) | ||||
t0 | 88±22 | 95±22 | 0.25 | |
t1 | 73±30 | 93±11 | <0.02 | |
Vasopressor (NA units#) | ||||
t0 | 0.14±0.16 | 0.18±0.23 | 0.63 | |
t1 | 0.12±0.23 | 0.07±0.10* | 0.36 | |
Fluid infusion (mL) | ||||
t0 (24 hours before) | 4.972±5.096 | 4.759±4.224 | 0.88 | |
t1 | 2.897±3.604 | 5.247±4.073 | 0.07 | |
Urine output (mL/kg/h) | ||||
t0 (24 hours before) | 2.21±2.17 | 2.35±2.14 | 0.83 | |
t1 | 0.95±1.03 | 2.5±1.73 | <0.05 | |
pH | ||||
t0 | 7.26±0.16 | 7.26±0.15 | 0.93 | |
t1 | 7.24±0.12 | 7.36±0.12** | <0.02 | |
Base deficit | ||||
t0 | -7.0±6.4 | -4.9±4.4 | 0.21 | |
t1 | -7.8±6.6 | -3.5±3.9 | <0.03 | |
PaO2/FiO2 | ||||
t0 | 209±77 | 304±182 | 0.08 | |
t1 | 194±116 | 388±334 | 0.10 | |
Glycemia (mg/dL) | ||||
t0 | 153±49 | 157±35 | 0.65 | |
t1 | 151±39 | 215±71*** | <0.008 | |
Lactate (mmol/L) (t1) | 1.4±0.5 | 1.9±0.9 | 0.24 | |
Hematocrit (%) (ti) | 30.5±7.6 | 30.1±5.8 | 0.84 | |
Sodium (mEq/L) (ti) | 147±8.7 | 149±7.2 | 0.46 | |
Creatinine (t1) | 1.8±2.3 | 0.8±0.6 | <0.05 |
t0 - first clinical assessment; t1 - before recovery; HR - heart rate; MAP - mean arterial pressure; PaO2/FiO2 - partial pressure of oxygen/fraction of inspired oxygen.
Uniformed doses of vasopressor agents in noradrenaline units. Differences between t0 and t1 in Phase 2:
p=0.053;
p=0.015;
p=0.001. Results expressed as absolute number and percentage, mean ± standard deviation.