Table 4.
Goals | Phase 1 | Phase 2 | p value | |
(N=18) | (N = 24) | |||
Time goals | ||||
Δtª 1st clin assessmt - confirm test. | 3 (16.7) | 11 (45.8) | <0.05 | |
<6 h | ||||
Δtb 1st clin assessmt - expiant <24 h | 1/8 (12.5)# | 10/18 (55.5)# | <0.05 | |
Fulfillment of all goals | 1/8 (12.5) # | 7/18(38.9) # | 0.178 | |
Temperature goals | ||||
Measurement of central temperature | 1 (5.6) | 13 (52) | <0.001 | |
Temperature >35ºC at 1st assessment | 16 (88.9) | 24 (100) | 0.09 | |
Temperature >35ºC on ICU exit | 16 (88.9) | 21 (87.5) | 0.89 | |
Fulfillment of all goals | 0 | 11 (45.8) | <0.001 | |
Ventilatory goals | ||||
PEEP=8-10 cmH2O | 2 (11.1) | 10 (41.7) | <0.03 | |
Tidal volume = 5-8 mL/kg | 0 | 9 (37.5) | <0.004 | |
Plateau pressure <30 cm H2O | 0 | 11 (45.8) | <0.001 | |
PaO2/FiO2 >300 on recovery | 2 (11.1) | 9 (37.5) | 0.06 | |
Fulfillment of all goals | 0 | 4 (16.6) | 0.07 | |
Fulfillment of goals without PaO2/FiO2 | 0 | 7 (29.1) | <0.02 | |
Hemodynamic goals | ||||
MAP >65 mmHg | 11 (61.1) | 21 (87.5) | <0.05 | |
Urine output >0.5 mL/kg/h - <4 ml/kg/h | 6 (33.3) | 15 (62.5) | 0.06 | |
Fulfillment of all goals | 3 (16.7) | 7 (29.1) | 0.34 | |
Hormone replacement goals | ||||
Methylprednisolone 15 mg/kg every 24 h | 6 (33.3) | 24 (100) | <0.001 | |
Levothyroxine 300 µ g enteral every 24 h | 0 | 21 (87.5) | <0.001 | |
Urine output >0.5 mL/kg/h - <4 mL/kg/h | 6 (33.3) | 15 (62.5) | 0.06 | |
Glucose <180 mg% on explant | 8 (44.4) | 8 (33.3) | 0.46 | |
Insulin IV when glycemia >180 mg/dL | 0 | 11 (45.8) | <0.001 | |
Sodium 130-150 mEq/L on explant | 12 (66.7) | 16 (66.6) | 1 | |
Fulfillment of all goals | 0 | 4 (16.6) | 0.07 |
ICU - intensive care unit; PEEP - positive end-expiratory pressure; PaO2 - partial pressure of oxygen; FiO2 - fraction of inspired oxygen; MAP - mean arterial pressure. # Percentage of the actual donor number. Results expressed as absolute number and percentage.