Table 1.
Summary of the articles found in MedLine that described drug-nutrient interactions
| Reference | Type of study | Comment |
| Mink et al.(3) | Prospective cohort | Non-blind study; analysis of drug-nutrient interactions was not the primary objective of the study; enteral administration was associated with lower serum levetiracetam |
| Bacopoulou et al.(4) | Prospective cohort | Non-blind study; there was no significant interaction between netilmicin and parenteral nutrition in neonates |
| Manessis et al.(5) | Prospective cohort | Non-blind study; serum levothyroxine levels were reduced concomitantly with enteral nutrition by a mechanism unrelated to adsorption to the feeding tube walls |
| Matsuba et al.(6) | Prospective cohort with historical control | Evaluated the introduction of a protocol to prevent obstruction of the feeding tube when drugs and dietary substances were simultaneous administered |
| Barichella et al.(7) | Randomized and prospective cohort | Non-blind study; reduction of the protein intake via enteral nutrition prevented a reduction in serum levodopa levels |
| Fay et al.(8) | Prospective cohort | Non-blind study; there was no significant interaction between levetiracetam and enteral nutrition |
| Kanji et al.(9) | Prospective cohort | Non-blind study; there was no significant interaction between gatifloxacin and enteral nutrition in the intensive care environment |
| Bailey & Briggs(10) | Cross-sectional study | Changes in the serum levels of several drugs concomitant with parenteral nutrition were evaluated |
| Dickerson et al.(11) | Retrospective case series | Enteral nutrition reduced the therapeutic effect of warfarin |
| Williams(12) | Case report | Voriconazole absorption was reduced by simultaneous enteral nutrition |
| Bonnici et al.(13) | Case report | Association between levodopa and high protein enteral nutrition favored the occurrence of the neuroleptic malignant syndrome |
| Cooper et al.(14) | Case report | High protein enteral nutrition decreased levodopa absorption |
| Krajewski & Butterfoss(15) | Systematic review | There was a significant interaction between warfarin and the enteral nutrition components |
| Salih et al.(16) | Systematic review | There was no significant interaction between anticonvulsants and parenteral nutrition |
| Wohlt et al.(17) | Systematic review | Few published reports existed regarding drug-nutrient interactions |
| Phillips & Nay(18) | Systematic review | There were no high-quality studies in the area, and the recommendations were based on weak levels of evidence |
| Dickerson(19) | Systematic review | Mechanism of interaction between warfarin and enteral nutrition |
| Williams(20) | Literature review | Recommendations for enteral nutrition and drug administration to minimize drug interactions. |
| Magnuson et al.(21) | Literature review | Mechanisms of the interactions and suggestions for their reduction |
| Harrington & Gonzalez(22) | Literature review | Review of the mechanisms of drug-nutrient interactions |