Table 3.
Univariate and multivariate analysis of factors associated with 30-day mortality in 109 patients treated with colistin
| Univariate analysis | Logistic regression | |||||
| Odds ratio | 95%CI | p value | Odds ratio | 95%CI | p value | |
| Men | 0.909 | 0.379-2.177 | 0.831 | |||
| Age (years) | 1.023 | 1.002-1.044 | 0.028 | 1.027 | 1.003-1.052 | 0.027 |
| APACHE II | 1.021 | 0.970-1.074 | 0.426 | |||
| SOFA at ICU admission | 1.040 | 0.929-1.163 | 0.495 | |||
| SOFA at the beginning of colistin treatment | 1.303 | 1.121-1.516 | 0.001 | |||
| Associated use of vancomycin | 1.522 | 0.601-3.857 | 0.368 | |||
| Associated use of amphotericin B | 1.622 | 0.174-15.111 | 0.658 | |||
| Associated use of aminoglycoside | 1.622 | 0.174-15.111 | 0.658 | |||
| Associated use of diuretics | 0.963 | 0.403-2.300 | 0.932 | |||
| Associated use of vasopressors | 11.175 | 4.247-29.402 | <0.001 | 12.485 | 4.492-34.703 | <0.001 |
| Mechanical ventilation | 0.833 | 0.083-8.332 | 0.875 | |||
| Empirical beginning of treatment | 2.105 | 0.861-5.149 | 0.103 | |||
| Concordance with positive cultures (n=79) | 0.437 | 0.113-1.689 | 0.230 | |||
| Days for beginning of treatment | 1.001 | 0.940-1.065 | 0.982 | |||
| Creatinine at ICU admission (mg/dl) | 1.010 | 0.744-1.370 | 0.950 | |||
| Creatinine at the beginning of treatment (mg/dl) | 1.187 | 0.812-1.734 | 0.365 | |||
| Acute kidney injury | 1.530 | 0.905-2.586 | 0.102 | |||
95%CI - 95% confidence interval; ICU - Intensive Care Unit; APACHE II - Acute Physiology and Chronic Health Evaluation II; SOFA - Sequential Organ Failure Assessment.