Table 1.
Demographic and treatment-related characteristics of the study population as predictors of extubation failure, controlled for gestational age and birth weight
| Variable | Failure | p value | |
|---|---|---|---|
| Yes N (%) | No N (%) | ||
| Gestational age | 0.017 | ||
| ≤28 weeks | 3 (12.5) | 5 (3.4) | |
| >28 to ≤32 weeks | 8 (33.3) | 35 (23.5) | |
| >32 to ≤36 weeks | 3 (12.5) | 47 (31.5) | |
| >36 weeks | 10 (41.7) | 62 (41.6) | |
| Weight | 0.005 | ||
| ≤1,000g | 12 (48.0) | 27 (18.0) | |
| 1,000g to ≤1,500g | 2 (8.0) | 43 (28.7) | |
| >1,500g to ≤2,000g | 3 (12.0) | 20 (13.3) | |
| >2,000g to ≤2,500g | 1 (4.0) | 21 (14.0) | |
| >2,500g | 7 (28.0) | 39 (26.0) | |
| Female gender | 15 (60.0) | 74 (49.0) | 0.631 |
| Antenatal corticosteroids | 11 (57.9) | 69 (53.9) | 0.475 |
| Surfactant | 16 (64.0) | 86 (57.0) | 0.619 |
| Postnatal corticosteroids | 23 (92.0) | 144 (95.4) | 0.227 |
| Xanthines | 9 (36.0) | 64 (42.4) | 0.551 |
| 1-minute Apgar | 5.1 (2.9) | 6.3 (2.4) | |
| 5-minute Apgar | 7.1 (2.7) | 8.2 (1.6) | 0.006 |
| MV length (days) | 5.0 (5.3) | 6.1 (7.8) | 0.051 |
| OT brand | 8.3 (1.4) | 8.5 (1.1) | 0.346 |
| Age at extubation | 6.3 (7.3) | 8.0 (9.2) | 0.023 |
| FiO2 | 26.6 (6.4) | 26.1 (8.9) | 0.624 |
| PIP | 14.8 (0.4) | 14.7 (0.7) | 0.592 |
| PEEP | 4.8 (0.4) | 4.7 (0.5) | 0.910 |
| TI | 0.3 (0.04) | 0.3 (0.03) | 0.941 |
| RR | 28.2 (5.2) | 27.5 (5.1) | 0.607 |
| MAP | 7.4 (0.8) | 7.0 (1.0) | 0.063 |
| Flow | 6.8 (0.8) | 6.9 (0.8) | 0.661 |
| pH | 7.36 (0.08) | 7.42 (0.09) | 0.019 |
| PaCO2 | 32.0 (10.1) | 31.7 (10.7) | 0.987 |
| PO2 | 100.4 (76.1) | 81.9 (39.5) | 0.099 |
| StO2 | 90.6 (7.2) | 90.2 (10.6) | 0.559 |
| Bicarbonate | 17.8 (3.3) | 19.9 (5.1) | 0.054 |
| BE | -5.1 (5.4) | -2.0 (5.4) | 0.020 |
MV - mechanical ventilation; OT - orotracheal tube; FiO2 - fraction of inspired oxygen; PIP - peak inspiratory pressure; PEEP - positive end-expiratory pressure; TI - inspiration time; RR - respiratory rate; MAP - mean airway pressure; pH - potential of hydrogen; PaCO2 - partial pressure of carbon dioxide; PO2 - partial pressure of oxygen; StO2 - oxygen saturation; BE - base excess.