Table 3.
Responses of pigs to vaccination with r-HN or r-HN/3A 93–143 chemically inactivated vaccines and r-HN challenge
| Vaccine a | Pig | Protection b | LPBE-antibody c (dpi) | 3ABC antibody d (dpi) |
|---|---|---|---|---|
| r-HN/3A93–143 |
3501 |
yes |
1:180 |
– |
| 3502 |
yes |
1:512 |
– |
|
| 3503 |
yes |
1:64 |
– |
|
| 3504 |
yes |
1:128 |
– |
|
| r-HN |
3505 |
yes |
1:90 |
– |
| 3505 |
yes |
1:256 |
– |
|
| 3507 |
yes |
1:256 |
– |
|
| 3508 |
yes |
1:32 |
– |
|
| Negative controls | 3509 |
no |
1:4 |
+ |
| 3510 | no | 1:4 | + |
aBinary ethyleimine-inactivated antigen vaccine, 2 μg/2 mL in one dose.
bPigs were challenged by intramuscular inoculation of 1000 ID50 of r-HN.
cLPBE-antibody, liquid-phase blocking ELISA antibody. Dpi here indicates four-weeks after vaccination that LPBE-antibodies were detected.
d3ABC antibody, the antibody to the nonstructural protein 3ABC of FMDV. Dpi here indicates three-weeks after challenge that 3ABC antibodies were detected. +, positive, −, negative.