Fig. 1.

The CFPMA pharmacophore model and in silico virtual screen. The common feature pharmacophore model was generated using a diverse set of antiadipogenic compounds. CFPMA is shown along with the inter-feature distance. The pharmacophore mapping of the MA compound, the LA compound (sinapinic acid), and virtual screen-identified hit rohitukine is shown. The actual % inhibition of MDI-induced lipid accumulation by molecule (^a) that was used in model generation as well as fit value (^b) generated on each molecule in pharmacophore mapping are shown next to the compound name.